The research group led by Dr Sjoerd van Wijk from the Institute of Experimental Cancer Research in Paediatrics at Goethe University already two years ago found evidence indicating that the anti-diarrhea drug loperamide could be used to induce cell death in glioblastoma cell lines. They have now deciphered its mechanism of action and, in doing so, are opening new avenues for the development of novel treatment strategies. In certain types of tumour cells, administration of loperamide leads to a stress response in the endoplasmic reticulum ER , the cell organelle responsible for key steps in protein synthesis in the body. The stress in the ER triggers its degradation, followed by self-destruction of the cells. This mechanism, known as autophagy-dependent cell death occurs when cells undergo hyperactivated autophagy.
Loperamide for diarrhoea. Side effects and dosage, loperamide. | Patient
We continue to receive reports of serious heart problems and deaths with much higher than the recommended doses of loperamide, primarily among people who are intentionally misusing or abusing the product, despite the addition of a warning to the medicine label and a previous communication. Loperamide is a safe drug when used as directed. The maximum approved daily dose for adults is 8 mg per day for OTC use and 16 mg per day for prescription use. Loperamide acts on opioid receptors in the gut to slow the movement in the intestines and decrease the number of bowel movements.
Loperamide is also used to reduce the amount of stool in people who have an ileostomy re-routing of the bowel through a surgical opening in the stomach. Loperamide may also be used for purposes not listed in this medication guide. You should not use loperamide if you are allergic to it, or if you have:.
If you are a consumer or patient please visit this version. Loperamide hydrochloride is a white to slightly yellow powder and is freely soluble in methanol, isopropyl alcohol, chloroform and slightly soluble in water. Its structural formula is:. Each capsule, for oral administration, contains 2 mg loperamide hydrochloride.